An herbal medicine orengedokuto prevents indomethacin-induced enteropathy.

Author

Miura, N., Fukutake, M., Yamamoto, M., Ohtake, N., Iizuka, S., Imamura, S., Tsuchiya, N., Ishimatsu, M., Nakamura, Y., Ishige, A., Watanabe, K., Kase, Y., Takeda, S.

Journal

Biol Pharm Bull.

Volume

30

Issue ID

3

Page

495-501

Date

2007 Mar

Keyword

Animals
 Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/toxicity
 Cyclooxygenase 2 Inhibitors/pharmacology
 Dinoprostone/metabolism
 Dose-Response Relationship, Drug
 Drugs, Chinese Herbal/pharmacology/*therapeutic use
 Duodenal Ulcer/chemically induced/mortality/*prevention & control
 Female
 Gastrointestinal Hemorrhage/prevention & control
 *Herbal Medicine
 Indomethacin/administration & dosage/*toxicity
 Injections, Subcutaneous
 Interleukin-10/metabolism
 Intestinal Mucosa/drug effects/metabolism/pathology
 Intestine, Small/drug effects/metabolism/pathology
 Leukocytes, Mononuclear/drug effects/metabolism
 Mice
 Mice, Inbred BALB C
 Nitrobenzenes/pharmacology
 Sulfonamides/pharmacology
 Survival Analysis
 Survival Rate
 Treatment Outcome

Abstract

Prostaglandin E2 (PGE2) is a key regulator of gastrointestinal, immunological, and mucosal homeostasis. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the prostaglandin-producing enzyme cyclooxygenases (COXs), and can induce serious complications, such as gastrointestinal damage, with long-term treatment. Orengedokuto (OGT), a Japanese traditional herbal medicine (Kampo medicine), is effective in various animal models of enteropathy. In the present study we examined whether OGT prevents enteropathy induced by NSAIDs in mice. Ulceration in the small intestine was induced with 2 subcutaneous injections of indomethacin (20 mg/kg body weight). Orally administered OGT prevented or reduced lethality, intestinal lesions, bleeding, increased serum nitrate/nitrite levels, and reduction of mucosal PGE2 induced by indomethacin. These beneficial effects of OGT were accompanied by increased production of PGE2 and effective therapeutic agent for the treatment of inflammatory bowel disease and adverse reactions to NSAIDs.

Language

eng