Development of Standardised Flavonoid extract (Cromolinex™) From Chromolaena odorata

Author

Ling S.K., Mastura M., Khoo M., Salbiah M., Nor Azah M.A., Saidatul Husni S., Vimala S., Mazura M.P., Ong B.K. & Abdull Rashih A. Medicinal Plants Programme, Division of Forest Biotchnology, Forest Research Institute Malaysia, 52109 Kepong, Selangor.     Tel: 03-62797356        Fax: 03-62729805    Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

Development of Standardised Flavonoid extract (Cromolinex™) From Chromolaena odorata

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2008)

Date

21st October - 22nd October 2008

Place Held

The Legend Hotel, Kuala Lumpur

Abstract

The fresh leaves and extracts of Chromolaena odorata (L.) King & Robinson (Asteraceae) ('pokok kapal terbang') are traditional herbal remedies in many countries for burns, soft tissue wounds and skin infections. Our study demonstrated that the leaf extract had anti-oxidant, anti-inflammatory and anti-staphylococcol properties with no cytotoxic effect on normal liver and kidney cells. The leaf extract was a mixture of compounds comprising mainly flavonoids and at least ten flavanoids have been isolated and identified. Due to their many biological and pharmacological activities, flavanoids have been added in food as functional ingredients, and in many cosmetic and dermatological formulations, mainly in the form of plant-derived extracts for their beneficial biochemical activity. Systematic attempts had been carried out to obtain flavonoid extract from the dried and powdered leaves of C. odorata. Effects of extraction parameters such as temperature, extraction time, material-solvent ratio and concentration of ethanol on the contents of flavonoids were investigated. On this basis, an extract, named ChromolinEx™ , showed enhanced anti-MRSA activity and there was no increase in cytotoxic effect on normal liver and and kidney cells. Basic cream and gel formulation study was conducted using ChromolinEx™ and essential oils of C. odorata. As a result, prototype cream and gel products for skin care (antiseptic and wound healing properties based on traditional claims) were developed. Further study will be carried out in order to provide comprehensive scientific evidence for developing the ChromolinEx™ into potential and affordable healthcare products.

Keywords

Chromolaena odorata; ChromolinEx™; flavonoid; anti-oxidants; anti-inflammatory

Session

Plenary: Session 3

Topic

Think Global, Act Local: A New Paradigm In Malaysian Herbal Industry (Prof. Emeritus Dr. Abdul Latif Ibrahim-UNISEL)