Anti-Inflammatory Activity of Piper Porphyrophylum N.E.BR.

Author

Farediah A., Emrizal & Hasnah M.S. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor Bahru.  Tel: 07-5534137  Fax: 07-5566162   Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Fadzureena J., Nik Musa'adah M. & Rasadah M.A. Medicinal Plants Programme, Forest Research Institute Malaysia (FRIM), Kepong 52109, Kuala Lumpur. Dayar A. Department of Pharmacy, Faculty of Science, Andalas University, Padang, Indonesia.

Language

English

Title

Anti-Inflammatory Activity of Piper Porphyrophylum N.E.BR.

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2008)

Date

21st October - 22nd October 2008

Place Held

The Legend Hotel, Kuala Lumpur

Abstract

Anti-inflammatory activity of crude extracts and isolated compounds of Piper prophyrophyllum N.E Br.. (Piperaceae) were confirmed with tetradecanoylphorbol acetate (TPA)-induced mouse ear oedema model and in vitro quantitative lipoxegenase inhibition assay. Nine compounds consisting of seven flavonoids, a flavanone and a lignin had been characterized from hexane and ethyl acetate extracts. The hexane extract showed significant activity, but none of the isolated compounds showed significant anti-inflammatory activity in the TPA-induced mouse ear oedema model. Meanwhile, only the hexane extract and compound, 4',5-dihydroxy-3',7-dimethoxyflavone, exhibited significant inhibitory activity against in vitro quantitative lipoxygenase inhibition assay.

Keywords

Piper prophyrophyllum; Piperaceae; flavones; lignin; anti-inflammatory activity

Session

Plenary: Session 3

Topic

Think Global, Act Local: A New Paradigm In Malaysian Herbal Industry (Prof. Emeritus Dr. Abdul Latif Ibrahim-UNISEL)