Toxicological Evaluation of Medicinal Plants Using Cell- Based Assay

Author

Khoo G.H.M., Rohana S., See N.J.K., Ling S.K.
Medicinal Plants Program, Forest Biotechnology Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor
Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Gentinq Klang, Setapak, 53300 Kuala Lumpur

Language

English

Title

Toxicological Evaluation of Medicinal Plants Using Cell- Based Assay

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2008)

Date

21st October - 22nd October 2008

Place Held

The Legend Hotel, Kuala Lumpur

Abstract

Herbal medicine is a multi-billion dollar industry. In order to explore the potentials of medicinal plants, we have studied various plant extracts for various therapeutic applications such as anti-Inflammatory, antioxidant, anti-microbial, anti-diabetic and biopesticidal. In this paper, we will discuss the findings related to toxicity of these extracts based on cell-based toxicity assay. Out of 100 extracts tested, two extracts were found to be cytotoxic towards normal liver (WRL-68) and normal kidney (Vero) cell lines. These extracts exhibited median inhibitory concentration (lC50) of less than 10 µg/mI. Nevertheless, these two plants (Garcinia mangostana and Goniothalamus umbrosus) were also widely used in traditional herbal remedies. For example, G. man gostana is well known world wide for its antioxidant properties and anti-cancer effects of xanthones derived from its pericarp. Goniothalamus umbrosus, on the other hand, is a lesser known plant but common among traditional practitioners as a plant that is good for anti-cancer therapy. This paper attempts to discuss Issues related to toxicity of these plants.

Keywords

Cytotoxicity; Garcinia mangostana; Goniothalamus umbrosus

Session

Poster Abstracts

Topic

Think Global, Act Local: A New Paradigm In Malaysian Herbal Industry (Prof. Emeritus Dr. Abdul Latif Ibrahim-UNISEL)