|Thailand||Ya Pak-king |
Murdannia loriformis ia a perennial herb of the Commelinaceae family. The roots are fibrous, 0.5 – 1 mm in diameter, glabrous or tomentose. The rhizomes are absent. The main stem is undeveloped; fertile stems are numerous arising from rosette, diffuse or ascending, measures 15-50 cm, glabrous or puberulent on one side, very rarely densely hirsute. The basal leaves with linear blade measure 5-15 cm x 6-9 cm, with cilated margins proximally; cauline leaves are shorter, ciliate only on one side of the sheath mouth, glabrous elsewhere. The cincinni terminal, solitary or 2 or 3 forming a panicle, subcapitate, of several densely arranged flowers; proximal involucral bracts are leaflike but smaller than the leaves. The distal ones are very small, less than 10 mm; peduncle 2.5 cm; bracts 4mm, caducous; pedicels slightly curved, 2.5-4 mm in fruit. The sepals ovate-elliptic, 3 mm, herbaceous. The petals are purple-red or blue, obovate-orbicular. The fetile stamens 2; filaments pubescent; staminodes 3; antherodes 3-sec. The capsule ovoid-globose, trigonous, 3-4 mm. The seeds 2 per valve, yellow-brown, radiate striate, finely white reticulate. 
Plant Part Used
In Thailand the fresh leaves of M. loriformis is used extensively to treat various kinds of cancer including those of liver, stomach, intestines, uterus and breast. It is also used to treat leukaemia. Some Thai traditional practitioners use this plant to treat cough, colds and inflammed wounds. It is also said to be able to reduce blood sugar levels. 
M. loriformis is widely used in Thailand to treat cancer patients. Vinitketkumnuen et al  found that the ethanolic extract had non-mutagenic effects on Salmonella typhimurium TA 100 and TA 98 with or without metabolic activation. It also had DT-diaphorase inducing activity on murine hepatoma (Hepa 1c1c7) and antimutagenicirty against MNNG and AFB  , IQ, Glu-P-1, Glu-P-2, Trp-P-1 and Trp-P-2 in modified Ames; test. It did not inhibit the mutagenesis induced NsN3, AF-2, and B(a)P.
Pornparsert et.al studied the antiploriferative and cytotoxic effects on the water and 80% ethanol extracts of the plant on five leukemic cell lines [Promyelocytic leukemia (HL60), T-cell leukemia (Molt4), B-cell leukemia (Daudi), Monocytic leukemia (U937) and erythroleukemia (K562)]. They did not find any anti-proliferative and cytotoxic effects on all tested cell lines.
In 2002 Intiyot et.al  published their results on the antimutagenicity of M. loriformis extracts in Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. Their results showed that M. loriformis did possess antimutagenic activity towards various known mutagens and it also inhibit AOM(azoxymethane)-induced aberrant crypt focus formation both in the initiation and post-initiation stages in the rat colon.
Anti-inflammatory, analgesic and antipyretic activityMs. Somja  in her masters thesis found that the ethanol extract of M. loriformis exhibited anti-inflammatory, analgesic and antipyretic properties. This is evidenced in the case of anti-inflammatory activity by its ability to inhibit paw oedema induced by carrageenin and arachidonic acid, inhibit granuloma and transudative formation with cotton pellets and reduced the increase alkaline phospatiase activity in serum to normal levels. She concluded that the anti-inflammatory effect is mediated through the inhibition of synthesis of inflammatory mediators through cyclooxygenase and lipoxygenase pathways on the one hand and due to its inhibitory effect on the proliferation of fibroblast and the synthesis of prostaglandins on the other hand and at the same time by stabilizing lysosomal membrane. The analgesic effect wa both in the early and late phases via inhibition of the synthesis of prostaglandins at the inflammed tissue sites and the spinal cord,. The antipyretic effects was based on inhibition of the synthesis and/or release of mediators, especially prostaglandins.
Adverse Effects in Human:
Used in Certain Conditions
Pregnancy / Breastfeeding
Neonates / Adolescents
Chronic Disease Conditions
Interactions with drugs
Interactions with Other Herbs / Herbal Constituents