Murdannia loriformis

Synonyms

Aneilema loriforme, Aneilema angustifolium, Aneilema nudiflorum, Aneilema terminale [1]

Vernacular Names:

Malaysia Rumput China
Thailand Ya Pak-king [2]
English Beijing Grass

General Information

Description

Murdannia loriformis ia a perennial herb of the Commelinaceae family. The roots are fibrous, 0.5 – 1 mm in diameter, glabrous or tomentose. The rhizomes are absent. The main stem is undeveloped; fertile stems are numerous arising from rosette, diffuse or ascending, measures 15-50 cm, glabrous or puberulent on one side, very rarely densely hirsute. The basal leaves with linear blade measure 5-15 cm x 6-9 cm, with cilated margins proximally; cauline leaves are shorter, ciliate only on one side of the sheath mouth, glabrous elsewhere. The cincinni terminal, solitary or 2 or 3 forming a panicle, subcapitate, of several densely arranged flowers; proximal involucral bracts are leaflike but smaller than the leaves. The distal ones are very small, less than 10 mm; peduncle 2.5 cm; bracts 4mm, caducous; pedicels slightly curved, 2.5-4 mm in fruit. The sepals ovate-elliptic, 3 mm, herbaceous. The petals are purple-red or blue, obovate-orbicular. The fetile stamens 2; filaments pubescent; staminodes 3; antherodes 3-sec. The capsule ovoid-globose, trigonous, 3-4 mm. The seeds 2 per valve, yellow-brown, radiate striate, finely white reticulate. [1]

Plant Part Used

No documentation

Chemical Constituents

No documentation

Traditional Used:

In Thailand the fresh leaves of M. loriformis is used extensively to treat various kinds of cancer including those of liver, stomach, intestines, uterus and breast. It is also used to treat leukaemia. [6]

Some Thai traditional practitioners use this plant to treat cough, colds and inflammed  wounds. It is also said to be able to reduce blood sugar levels. [7]

Pre-Clinical Data

Pharmacology

Anticancer activity

M. loriformis is widely used in Thailand to treat cancer patients. Vinitketkumnuen et al [3] found that the ethanolic extract had non-mutagenic effects on Salmonella typhimurium TA 100 and TA 98 with or without metabolic activation. It also had DT-diaphorase inducing activity on murine hepatoma (Hepa 1c1c7) and antimutagenicirty against MNNG and AFB [1] , IQ, Glu-P-1, Glu-P-2, Trp-P-1 and Trp-P-2 in modified Ames; test. It did not inhibit the mutagenesis induced NsN3, AF-2, and B(a)P.

Pornparsert et.al studied the antiploriferative and cytotoxic effects on the water and 80% ethanol extracts of the plant on five leukemic cell lines [Promyelocytic leukemia (HL60), T-cell leukemia (Molt4), B-cell leukemia (Daudi), Monocytic leukemia (U937) and erythroleukemia (K562)]. They did not find any anti-proliferative and cytotoxic effects on all tested cell lines.

In 2002 Intiyot et.al [4] published their results on the antimutagenicity of M. loriformis extracts in Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. Their results showed that M. loriformis did possess antimutagenic activity towards various known mutagens and it also inhibit AOM(azoxymethane)-induced aberrant crypt focus formation both in the initiation and post-initiation stages in the rat colon.

Anti-inflammatory, analgesic and antipyretic activity

Ms. Somja [5] in her masters thesis found that the ethanol extract of M. loriformis exhibited anti-inflammatory, analgesic and antipyretic properties. This is evidenced in the case of anti-inflammatory activity by its ability to inhibit paw oedema induced by carrageenin and arachidonic acid, inhibit granuloma and transudative formation with cotton pellets and reduced the increase alkaline phospatiase activity in serum to normal levels. She concluded that the anti-inflammatory effect is mediated through the inhibition of synthesis of inflammatory mediators through cyclooxygenase and lipoxygenase pathways on the one hand and due to its inhibitory effect on the proliferation of fibroblast and the synthesis of prostaglandins on the other hand and at the same time by stabilizing lysosomal membrane. The analgesic effect wa both in the early and late phases via inhibition of the synthesis of prostaglandins at the inflammed tissue sites and the spinal cord,. The antipyretic effects was based on inhibition of the synthesis and/or release of mediators, especially prostaglandins.

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Flora of China (http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=240001477) Accessed on: 26th July 2010
  2. (http://www.ecologyasia.com/news-archives/2003/may-03/bangkokpost_030529_2.htm) Accessed on: 26th July 2010
  3. Usanee Vinitketkumnuen; Wiriya Charoenkunathum; Prachya Kongtawelert; Nirush Lertprasertsuke; Porntipa Picha; Taijiro Matsushima Antimutagenicity and DT-Diaphorase Inducer Activity of the Thai Medicinal Plant, Murdannia loriformis Journal of Herbs, Spices & Medicinal Plants, September 1996 Volume 4(1): 45 - 52
  4. Intiyot Y, Kinouchi T, Kataoka K, Arimochi H, Kuwahara T, Vinitketkumnuen U, Ohnishi Y. Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. J Med Invest. 2002 Feb;49(1-2):25-34.
  5. Miss Siriporn Somja  Anti-inflammatory, Analgesic and Antipyretic Activities of Ethanol Extract from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy Master of Science (Pharmacology) Chiang Mai University 1964 (http://library.cmu.ac.th/digital_collection/etheses/fulltext.php?id=458#) Accessed 26th July 2010
  6. Thai Medicinal Plants (http://www.yohea.info/plants.shtml) Accessed on 27th July 2010
  7. Thai Herbal Products (http://www.thaiherbalproducts.com/catalog/murdannia_loriformis_ya_pak_king_beijing_grass.html?retcat=13) Accessed on 27th July 2010