Mo Han Lian

Eclipta alba

Chemical Constituents

E. alba contains three major coumestans: norwedelolactone, wedelolactone, and demethylwedelolactone. Also, flavonoids, steroids, triterpenoids, polyacetylenes, and thiophene derivatives. [4][5][6]

Dosage

9 to 15 grams prepared herb. [1]

Pharmacology

Pre-clinical

Traditional

Properties of Mo Han Lian are sweet sour and cool. It works throught the kidney and liver channels where it nourishes the yin and cools heat. More current uses indicate that it may be used topically to treat dampness related disorders of the perineum. [1] 

Mo Han Lian is used to cool the blood and stop bleeding from various sources mostly due to heat in the blood. 

Mo Han Lian is also traditionally used as an anti-venom against snakebite. [3] 

General 

Anti-hypertensive

In one small clinical study of mildly hypertensive males aged 45 to 50, Mo Han Lian users showed a reduction in mean arterial pressure, total cholesterol, triglycerides, plasma lipid peroxides and LDL fraction. Its use also resulted in an increased urine output. [7] 

Other

Mo Han Lian is astringent, emetic, febrifuge, purgative and tonic. [4] Actual clinical work on Mo Han Lian is limited with only a few small pilot studies published in the literature. However its traditional use has been further verified and investigated in animal studies. These studies have shown positive results for Mo Han Lian as having hepatoprotective properties, [8] anti-aggressive neurological effects, [9] and positive effect on memory, [10] anti-inflammatory properties and analgesic properties. [11] 

Clinical

No documentation.

Interaction and Depletions

Interaction with other Herbs

No documentation.

Interaction with Drugs

Based on pharmacology, do not use in combination with diuretics or medications for hypertension. [7]

Precautions and Contraindications

Side effects

Not to be used in those with Stomach weakness or in those with deficiency of kidney Qi. Not to be used in those with Spleen cold due to deficiency. [1] 

Not to be used by those with high blood pressure without supervision of a medical professional.

Pregnancy

Not to be used by pregnant or nursing women.

Age limitation

Not to be used by children.

Adverse reaction

Mo Han Lian is sometimes found to be adulterated with other botanicals that grow in the same areas. [1] further references. The max-lethal dose was found to be 5000mg / kg body weight. [2] LD50 in mice by intraperitoneal administration was >2g/kg. [3] 

References

  1. Z. You-Ping. Chinese Matria Medica: Chemistry, Pharmacology and Applications. Florida:CRC Press;1998. 838-839.
  2. V. K. Lal, K. Amit, K. Prashant, S.Y. Kuldeep. Screening of Leaves and Roots of Eclipta alba for Hepatoprotective Activity. Archives of Applied Science Research.2010;2(1):86-94.
  3. Z. You-Ping. Chinese Matria Medica: Chemistry, Pharmacology and Applications. Florida:CRC Press;1998:647.
  4. M.S. Premila. Ayurvedic Herbs: A Clinical Guide to the Healing Plants of Traditional Indian Medicine. Binghamton, NY: The Hayworth Press; 2006.
  5. R.K. Upadhyay, M.B. Pandey, R.N. Jha, V.B. Pandey. Eclalbatin, a triterpene saponin from Eclipta alba. J Asian Nat Prod Res. 2001;3(3):213-217.
  6. Nadkarni AK, Indian Materia Medica, Vol. 1. 3rd Edition. Bombay: Popular Prakashan Pvt. Ltd;1982.
  7. Rangineni V, Sharada D, Saxena S. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects; a pilot study. J Med Food. Mar2007; 10(1): 143-148.
  8. Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK.In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol. Oct2001;45(4):435-441.
  9. Lobo OJ, Banji D, Annamalai AR, Manavalan R. Evaluation of antiagessive activity in Eclipta alba in experimental animals. Pak J Pharm Sci. Apr2008; 21(2):195-199.
  10. Banji O, Banji D, Annamalai AR, Manavalan R. Investigation on the effect of clipta alba on animal models of learning and memory. Indian J Physiol Pharmacol. Jul-Sep2007; 51(3): 274-278.
  11. Sawant M, Isaac JC, Narayanan S. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytother Res. Feb2004; 18(2): 111-113