Mimosa pudica

Synonyms

Mimosa hirsuta, Mimosa hispidula, Mimosa pudibunda [1] [6]

Vernacular Names:

Malaysia

Malu-malu, Semalu, Puteri malu, Kembang gajah, Rumput rimau, Memalu, Kemuncup, Keman  ; Rumput rimau, Kommon (Kadazan), Todop-todop (Kadazan-Dusun)

English Common sensitive plant; Humble plant
Indonesia

Putri malu, Sikejut (Indonesian), Kucingan, Piskucing (Javanese) ; Si hirput, Si kerput(Batak), Sikajuik (Minangkabau),  Jukuk ancing (Lampung), Bujang kagit, Jukut borang, Jukut borangan, Jukut gehgehran, Jukut riyud, Rondo kagit (Sunda), Randelik, Ri sirepan (Jawa), Rebha lo-malowan, Rebha dus-todusan (Madura), Padang getap (Bali), Daun kaget-kaget (Manado),  Daun rebah bangun (Melayu) [6]

Thailand

Yaa pan yot

Philippines

Torog-torog (Bicolano), Hibi-hibi (Bisaya, Cebuano), Babain, Bain-bain, Dilgansusu (Ilocano), Huya-huya (Ilongo), Malamarine (Pampango), Makahiya, Makahiyang babae (Tagalog)

Lao PDR

Nya nyoub

Myanmar

Tee-ka-yone

Vietnam

Trinh nu thai

China

Han xiu cao

India

Lajauni; Lajjaalu, Laajavanti, Namaskaari, Samangaa, Samkochini, Shamipatraa, Khadirkaa, Raktapaadi (Ayurvedic); Munuguda-maramu, Muttavapulagamu-chettu (Telegu), Totalvadi. Thotalpadi, Thottal shurungi, Thottasiningi, Thottalvadi (Tamil), Thottamvati, Thendarmani (Malayalam) [2]

Bangladesh Kajjabati
France Sensitive commune, Herbepudique ou Vive mimuese
German Shaamhafte sinnplauze, Fuhl-planze
Trinidad and Tobago Ti marie, Mese marie [1] [2] [6] [9] [10] [11]

General Information

Description

Mimosa pudica is a member of the Fabaceae family. It is diffusely spreading, slightly  woody annual or  perennial herb. The stems branched, up to 1 m high, sparingly prickly and with numerous bristle hairs bent downward. The leaves alternate and bipinnate, very sensitive, both the pinnae and leaflets falling when touched. Pinnae usually 4, subdigitate at apex of bristly petiole. Two lance-shaped stipules at base of petiole. The leaflets narrowly oblong in shape, sharply pointed, sides straight, measuring 1-1.5 cm long, sessile, covered with fine bristles. The flowers numerously arranged in heads nearly 1 cm in diametre, long peduncled, solitary or 2 or 3 in each axil. The flowers pink in colour while the stamens 4 in number. The pods flat, slightly curved outward or backward, numerous, measure 1-2 cm long, made up of 3  to 5-seeded joints that open at maturity and fall away from the persistent armed sutures with hairs numerous, weak, spreading and yellow-white bristles. The seeds obovate in shape, measuring 2 x 1.5 mm and brown in colour. The seedlings emerge as a single stem bearing cotyledons and the once-pinnate first true leaf; subsequent leaves bipinnate.[1]

Plant Part Used

Whole plant, leaves, root [3] [4] [6]

Chemical Constituents

7, 8, 3', 4'-tetrahydroxyl-6-C-[alpha-L-rhamnopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl flavone); 5, 7, 4'-trihydroxyl-8-C-[alpha-L-rhamnopyranosyl-( --> 2)]-beta-D-glucopyranosyl flavone; 5, 7, 3', 4'-tetrahydroxyl-6-C-[alpha-L-rhamnopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl flavone; ascorbic acid; beta-carotene; crocetin; crocetin-dimenthyl-ether; catcher; mimosine; norepinephrine; thiamin; [8] [12]

Traditional Used:

Gastrointestinal Disease

In traditional Indian medicine M. pudica is an important ingredient in the treatment of haemorrhoids, diarrhea, persistent dysentery. For haemorrhoids it is incorporated in an ointment preparation. Decoction of the leaves help relieve diarrhea.[2] [8]

Respiratory Disease

The roots of M. pudica are used to treat bronchitis, asthma and productive cough.[6]

Gynaecological And Obstetrical Diseases

In the 16th century, M. pudica is a popular herb for treating diseases of the female genital tract. In Trinidad and Tobago the plant is used to ease childbirth and also to render the women infertile. As a post partum treatment Mimosa pudica is prescribed by the midwives of Malaysia to help cleanse the external genitalia and causes the shrinkage of the vaginal canal. The Nicaraguan and Mexicans make use of the plant to stop excessive menstrual bleeding.[2] [4] [5] [8]

Neurological Diseases

A bath of the decoction of the whole plant relieves insomnia. The Mexicans and the Vietnamese use the decoction of the dried leaves to alleviate depression. The drug is also used to treat convulsions and neurasthenia.[3] [4] [5]

Genito-urinary Diseases

A decoction of leaves or roots acts as a diuretic and is used to treat stones in the urinary tract. The roots in the form of a decoction are used to treat various renal and urinary tract diseases including gonorrhea, dysuria, lithiasis and haematuria. It is also used in the treatment of hydrocele.[3] [6] [8] [10] [11]

Inflammatory Diseases

The leaves have great value in inflammatory diseases. A paste of the leaves is rubbed over glandular swellings, applied over cuts and wound, sores, ulcers and herpes zoster. The decoction of the leaves can treat acute conjunctivitis, high fever in children, coryza and bad effects of cold including influenza and acute otitis.[4] [6] [7]

Other uses

The roots are mixed with other ingredients to make a tonic for maintaining health and vitality. Decoction of the roots helps relieve giddiness, headache and fever. Restless children are bathed with a decoction of the plant. To firm up the breast the Malay community made use of the plant pounded with two Areca catechu fruit and some salt. This is applied nightly.[9] [10]

Pre-Clinical Data

Pharmacology

Contraceptive activity

One of the traditional uses of M. pudica is as an antifertility medicine. In Assam the roots of M. pudica is used as a temporary birth control medicine.[13] Study[14] observed that the oestrus cycle pattern in female rats were altered. This was evidenced by the absent of nucleated and cornified cells, smear was chacterized by leucocytes only as in dioetrus and there was significant reduction in the number of normal ova and a significant increase in the number of degenerated ova. Study[15] confirmed this effects when they found that the methanol extract of dried roots could prolong the oestrus cycle, disturbs the secretion of gonadotropin hormones and decrease FSH level in proestrus and oestrus stages.

Urolithiasis activity

Study[16] could not demonstrate any effects of M. pudica on either preventing stone deposition or dissolving performed stones.

Anthelmintic activity

In the screening study of six Jamaican medicinal plants against filiariform larvae of Strongyloides stercoralis, Study[17] found extracts of M. pudica could inhibit the larvae within 1 hour of exposure.

Antivenom activity

Reports[18] found that the aqueous extract of the roots of M. pudica had significant inhibitory effect on the lethality, myotonicity and tested enzyme activities of venom of Naja kaouthia. Anothe study[19] found that amongst the enzymes inhibited by the aqueous extract of M. pudica root included hyaluronidase and protease from Indian snake venoms (Naja naja, Vipera russelii and Echis carinatus)

Anticonvulsant activity

Decoction of the leaves of M. pudica was able to inhibit convulsions induced by pentylentetetrazol and strychnine but not against picrotoxin-induced ones. It also antagonized N-methyl-D-aspartate-induced turning behavior.[20]

Antidepressant activity

Study[21] found that aqueous extracts of dried leaves of M. pudica was able to reduce the immobility in the forced swimming test and increased the rate of reinforcers received in the DRL-72s test. These results is suggestive of the presence of antidepressant effects in rats.

Antidiabetic activity

Study[22] found that by giving the ethanolic extract of leaves of M. pudica at a dose of 250mg/kg to mice they could produce a significant hypogylcaemic effects.

Wound healing activity

Study[23] on the wound healing activity of aqueous and methanol extracts of roots of M. pudica. They found that these extracts possesses significant wound healing properties probably due to the high phenol content in them.

Antiasthmatic activity

The ethanol extract of the whole plant of M. pudica showed inhibitory activity on asthmatic attack induced by ovalbumin in BALB/c mice. It was found to inhibit HMC-1 cell migration induced by stem cell factor and blocked the release of monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) in EoL-1 cells. There was also suppression of Leukocytosis, eosinophilia and mucous hypersecretion, features common in asthma.[24]

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

    1. Marita Ignacio Galinato, Keith Moody, Colin M. Piggin, International Rice Research Institute, Upland rice weeds of south and southeast Asia, IRRI, Philippine, 1999. pg53
    2. C. P. Khare, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage, Botany, Springer, New York, 2004. pg313
    3. Harald W. Tietze, Juta Stepanovs, Love Remedies, Harald W.Tietze Publishing Pty/Ltd, Australia,  2000. pg68
    4. Hwee Ling Koh, Chua Tung Kian, Chay Hoon Tan, A guide to medicinal plants: an illustrated, scientific and medicinal approach, World Scientific Publishing Co. Pte. Ltd., Singapore, 2009.  pg99-100
    5. M.Wanita, 1001 misteri alam: menyingkap rahsia khasiat sumber alam semula jadi, Buku Prima Sdn Bhd, Selangor, 2008.  pg155-156
    6. Setiawan Dalimartha, Atlas tumbuhan obat Indonesia, Volume 2, Niaga Swadaya, Jakarta, 2006. pg157-159
    7. Kumar B.,  Electropathy Philosophy (hindi), B. Jain Publisher (P) Ltd, New Delhi, 2002. pg1690
    8. Cheryl Lans, Creole Remedies of Trinidad and Tobago, Lulu.com, 2007. pg83-116
    9. Muhamad Zakaria & Mustafa Ali Mohd, Traditional Malay Medicinal Plants, Institut Terjemahan Negara Malaysia Berhad, Kuala Lumpur, 2010. pg101
    10. Kamarudin Mat-Salleh, A. Latiff, Tumbuhan Ubatan Malaysia, Pusat Pengurusan Penyelidikan Universiti Kebangsaan Malaysia, Selangor, 2002. pg381-382
    11. H. Panda, Herbs cultivation and medicinal uses, National Institute of Industrial Research, India, 2000. pg355
    12. Yuan K, Lü JL, Yin MW. [Chemical constituents of C-glycosylflavones from Mimosa pudica] Yao Xue Xue Bao. 2006 May;41(5):435-8.
    13. Tiwari KC, Majumder R, Bhattacharjee S. Folklore information from Assam for family planning and birth control. Int J Crude Drug Res. 1982 Nov;20(3):133-7.
    14. Valsala S, Karpagaganapathy PR. Effect of Mimosa pudica root powder on oestrous cycle and ovulation in cycling female albino rat, Rattus norvegicus. Phytother Res. 2002 Mar;16(2):190-2.
    15. Ganguly M, Devi N, Mahanta R, Borthakur MK. Effect of Mimosa pudica root extract on vaginal estrous and serum hormones for screening of antifertility activity in albino mice. Contraception. 2007 Dec;76(6):482-5.
    16. Joyamma V, Rao SG, Hrishikeshavan HJ, Aroor AR, Kulkarni DR. Biochemical mechanisms and effects of Mimosa pudica (Linn) on experimental urolithiasis in rats. Indian J Exp Biol. 1990 Mar;28(3):237-40.
    17. Robinson RD, Williams LA, Lindo JF, Terry SI, Mansingh A. Inactivation of Strongyloides stercoralis filariform larvae in vitro by six Jamaican plant extracts and three commercial anthelmintics. West Indian Med J. 1990 Dec;39(4):213-7.
    18. Mahanta M, Mukherjee AK. Neutralisation of lethality, myotoxicity and toxic enzymes of Naja kaouthia venom by Mimosa pudica root extracts. J Ethnopharmacol. 2001 Apr;75(1):55-60.
    19. Girish KS, Mohanakumari HP, Nagaraju S, Vishwanath BS, Kemparaju K. Hyaluronidase and protease activities from Indian snake venoms: neutralization by Mimosa pudica root extract. Fitoterapia. 2004 Jun;75(3-4):378-80.
    20. Ngo Bum E, Dawack DL, Schmutz M, Rakotonirina A, Rakotonirina SV, Portet C, Jeker A, Olpe HR, Herrling P. Anticonvulsant activity of Mimosa pudica decoction. Fitoterapia. 2004 Jun;75(3-4):309-14.
    21. Molina M, Contreras CM, Tellez-Alcantara P. Mimosa pudica may possess antidepressant actions in the rat. Phytomedicine. 1999 Nov;6(5):319-23.
    22. Amalraj T, Ignacimuthu S. Hyperglycemic effect of leaves of Mimosa pudica Linn. Fitoterapia. 2002 Jul;73(4):351-2.
    23. Kokane DD, More RY, Kale MB, Nehete MN, Mehendale PC, Gadgoli CH. Evaluation of wound healing activity of root of Mimosa pudica. J Ethnopharmacol. 2009 Jul 15;124(2):311-5.
    24. Yang EJ, Lee JS, Yun CY, Ryang YS, Kim JB, Kim IS. Suppression of ovalbumin-induced airway inflammatory responses in a mouse model of asthma by Mimosa pudica extract. Phytother Res. 2010 Jul 7.