Neuroprotective Activity of Galloylated Cyanogenic Glucosides and Hydrolysable Tannins from the Leaves of Phyllagathis Rotundifolia (Jack) Blume

Author

Tan H.P, Daniel Z.H. Wong, Ling S. K., Habsah A. Kadir, Chuah C. H.
Medicinal Plants Division, Forest Research institute Malaysia, 52109 Kepong, Selangor
Chemistiy Department, Faculty of Science. University of Malaya, 50603 Kuala Lumpur
Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur
Tel: 603-62797671 E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

Neuroprotective Activity of Galloylated Cyanogenic Glucosides and Hydrolysable Tannins from the Leaves of Phyllagathis Rotundifolia (Jack) Blume

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2010)

Date

3rd August - 4th August (2010)

Place Held

Forest Research Institute Malaysia(FRIM)

Abstract

Neurodegenerative diseases such as Alzheimer’s disease, Parkison’s disease, stroke, and dementia is causing 8% of total death rate in all over the world. Oxidative stress-induced cell damage mediated by reactive oxygen species (ROS), mainly superoxide anion and hydrogen peroxide, has been shown to be involved in these severe neuronal diseases. A number of antioxidant studies have been reported on hydrolysable tannins. Limited information however is found for H202-induced neuroprotective activity in hydrolysable tannins. NG1O8-15 hybridoma cell lines have been widely used as neuron model in physiological and pharmacological research. The galloylated cyanogenic glucosides (Prunasin 2’,3’.4’,6-tetra-O-gallate) and hydrolysable tannins (1,2,3,4,6-penta-O-galloyl-β-D-glucose, Pterocarinin C and Praecoxin B) isolated from the leaves of Phyllagathis rotundifolia (Jack) Blume exhibited high percentage of cell viability against H202-induced oxidative stress on pre-incubation treatment of NG 108-15. These compounds significantly protected NG 108-15 cells in concentration-dependent manner
(6.25-100 µM).

Keywords

neuroprotection; galloylated cyanogenic glucosides; hydrolysable tannins Phyllagathis rotundifolia (Jack) Blume

Session

Session 2: Oral 10

Topic

Harnessing the Tropical heritage: Recent Advances in R&D and commercialization