Antifungal Activity of Some Medicinal Plants

Author

Ahmad-Raus R., Jamal P., Erlina A. and Addnan N.H.
Department of Biotechnology Engineerin, Kulliyyah of Engineering, International Islamic
University of Malaysia, Jalan Gombak, 53100 Kuala Lumpur
TeI. 03-6 1964588
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

Antifungal Activity of Some Medicinal Plants

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2010)

Date

3rd August - 4th August (2010)

Place Held

Forest Research Institute Malaysia(FRIM)

Abstract

Natural products have long been providing important drugs for infectious diseases including fungal infections that are known to be the main cause of death in immuno-compromised patients. Plants are known to produce a lot of secondary metabolites which are recognized as a useful source of new drugs. In this study, the extraction of seven potential medicinal plants for antifungal compounds in four different solvents (distilled water, methanol, ethyl acetate and hexane) was carried out. The extraction parameters were set at 300 rpm agitation for 10 h at room temperature. Agar disc diffusion method against Aspergillus nige, A. fumigatus and Fusarium solani was adopted for the determination of antifungal activity. The plants studied were Vallaris glabra Kuntze (‘kesidang’), Mussaenda philippice A. Rich. (bunga janda kaya kuning’), Clerodendrum paniculatum L. (‘pokok pagoda’), Artocarpus elasticus Reinw. ex Blume (‘pokok terap’). Alpinia galanga Willd. (‘lengkuas’), Cassia alata L. (‘gelenggang besar’) and Curcuma longa L. (kunyit’). Only methanol, ethyl acetate and hexane extracts of A. galanga showed inhibition of growth against all tested organisms. All the other plants did not exhibit antifungal activity. The methanol extract of A. galanga (MIC value = 1.25 mg/ml) showed the highest antifungal activity compared to the other two types of extract. This study suggested that A. galanga could be considered as a potential plant for further studies.

Keywords

Antifungal; medicinal plants; solvent extracts

Session

Poster Abstracts: P05

Topic

Harnessing the Tropical heritage: Recent Advances in R&D and commercialization