In-Vitro Anti-Inflammatory and Antioxidant Evaluation of Leaf Extract of Baeckea Frutescens L.

Author

Fadzureena J., Mazura M.P, Vimala S., Hani I.B. & Nor Farizan M.N. Bloactivity Programme, Medicinal Plant Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor Tel: 03-6279 7607 E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

In-Vitro Anti-Inflammatory and Antioxidant Evaluation of Leaf Extract of Baeckea Frutescens L.

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2010)

Date

3rd August - 4th August (2010)

Place Held

Forest Research Institute Malaysia(FRIM)

Abstract

Baeckea frutescens L. is a shrub or small tree of the family Myrtaceae locally known as “cucur atap” found in Sumatra, the Malay Peninsula and the coasts of southern China to Australia. The leaves of B. frutescens were extracted using methanol and fractionated to hexane, chloroform, ethyl acetate and water fractions. The extract and fractions were then tested in vitro against anti-inflammatory and antioxidant bioassays. The anti-inflammatory activities were evaluated using three enzyme based assays, hyaluronidase, lipoxygenase and xanthine oxidase. The anti-oxidant activities were analyzed via DPPH radical scavenging assay and superoxide scavenging assay. Various degrees of inhibitions towards all enzymes for anti-inflammatory activities were observed. The most significant activity noted was from the methanol extract in lipoxygenase assay (76.67±3.28). Ethyl acetate fraction on the other hand showed moderate activity in xanthine oxidase assay. Additionally, extract and all fractions from B. frustescens leaves showed high activity in the two anti-oxidant assays.

Keywords

Baeckea frutescens; cucur atap; anti-inflammatory; anti-oxidant

Session

Poster Abstracts: P41

Topic

Harnessing the Tropical heritage: Recent Advances in R&D and commercialization