Author
Sliutz G, Speiser P, Schultz AM, Spona J, Zeillinger R
Date
5/1993
Journal
Horm Metab Res
Abstract
In our studies on prolactin inhibition by plant extracts we focused on the effects of extracts of Vitex agnus-castus and its preparations on rat pituitary cells under basal and stimulated conditions in primary cell culture. Both extracts from Vitex agnus-castus as well as synthetic dopamine agonists (Lisuride) significantly inhibit basal as well as TRH-stimulated prolactin secretion of rat pituitary cells in vitro and as a consequence inhibition of prolactin secretion could be blocked by adding a dopamine receptor blocker. Therefore because of its dopaminergic effect Agnus castus could be considered as an efficient alternative phytotherapeutic drug in the treatment of slight hyperprolactinaemia.
