Interaction type:
Depletions
Interaction rating:
Study Supported
An animal study reported that this medication decreases melatonin levels in the pineal body, the site of melatonin production in the brain. Supplementation with the affected nutrient may be necessary. (1)
References
- View Abstract: Wakabayashim H, Shimada K, et al. Effect of Psychotropic Drugs on the Contents of Melatonin, Serotonin and N-acetylserotonin in Rat Pineal Gland. Jpn J Pharmacol. Feb1989;49(2):225-34.