Fenugreek ( Trigonella foenum-graecum ) : Interaction with antidiabetic medications
Interaction type:
Interactions
Interaction rating:
Potential/Theoritical
Based on pharmacology:
Interactions of fenugreek with known antidiabetics metformin have been evaluated in several chemically induced diabetic animal models. The combination of fenugreek (150 mg/kg) and metformin (100 mg/kg) produced a significant reduction in plasma glucose level (20.7%) in type 2 diabetes (1).
In one randomised study, 46 patients taking sulfonylureas with fasting blood glucose levels of 7 to 13 mmols/L were given fenugreek saponins 2.1g (capsule) three times daily after meals for 12 weeks. When compared with 2 similar patients given placebo it was found that fenugreek saponins decreased the fasting blood glucose level by 23% (8.38mmol/L versus 6.79 mmol/L) (2)
References
- Neha S, Anand K, Sunanda P. Administration of fenugreek seed extract produces better effects in glibenclamide-induced inhibition in hepatic lipid peroxidation: an in vitro Study. Chinese journal of integrative medicine. 2019 Apr;25(4):278-84. Pdf : https://www.deepdyve.com/lp/springer-journal/administration-of-fenugreek-seed-extract-produces-better-effects-in-r7Qzh10P02?key=springer
- Lu FR, Shen L, Qin Y, Gao L, Li H, Dai Y. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. Chinese Journal of Integrative Medicine. 2008 Mar;14(1):56-60. PDF : https://www.deepdyve.com/lp/springer-journal/clinical-observation-on-trigonella-foenum-graecum-l-total-saponins-in-vIZJ0fFl0F?key=springer
