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Ficus elastica Roxb.

Synonyms

No documentation

Vernacular Names:

Malaysia Rambong, Pokok Getah Rambong. [2]

General Information

Description

Ficus elastica is a member of the Moraceae family. It is a big shrub or tree. The leaves are large, leathery, oblong to elliptic and bluntly caudate with rounded or narrowed base. It has a prominent midrib and very fine, closely paralleled nerves. It measures 20cm long and 13cm wide with petioles 5cm long. The stipules are 17cm long and red in colour. The figs are sessile in pairs, ovate-oblong and greenish yellow in colour. They are 12cm long. [1]

Plant Part Used

Leaves [2]

Chemical Constituents

Ficaprenol-11, ficusamide; ficusoside; elasticoside. [3] [4]

Traditional Used:

Very young leaf-tips are eaten in Java in salad.[2] In West Africa the plant is used to treat muscle and joint pains. [2] [6]

Pre-Clinical Data

Pharmacology

Cytotoxic activity

Ficusamide isolated from the bark of aerial roots of F. elastica showed moderate in vitro growth inhibitory activity against the human A549 lung cancer cell line. However, the methanol extract of the leaves did not show any genotoxic or cytotoxic activities. [4][5]

Antimicrobial activity

Fucosamide was found to strongly inhibit Staphylococcus saprophyticus and elasticoside is potent against Enterococcus faecalis. [4]

Antiinflammatory activity

The aqueous extract of F. elastica was found to inhibit both the primary and secondary lesions of adjuvant arthritis in rats. These actions are comparable to indomethacid. This activity is attributed to the probable presence of flavonoids in the extract. [6]

Cross-reactivity activity

In a study on cross-reactivity between latex of Hevea brasilensis and F. elastica. It was found that the 9 patients with systemic type I hypersensitivity to latex of H. brasilensis did not react to the latex of F. elastica. [7]

Toxicities

No documentation

Teratogenic effects

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

1. Ridley HN. Flora of the Malay Peninsula Volume 3 L. Reeves & Co.,London. 1923 pg. 334.
2. Burkill IH. A Dictionary of Economic Products of the Malay Peninsula Volume 1, Ministry of Agriculture and Cooperatives Malaysia, Kuala Lumpur.1966, pg.1024 – 1025
3. Tanaka Y, Takagi M. Structural characterization of ficaprenol-11 by 13C nuclear magnetic resonance. Biochem J. 1979 Oct 1;183(1):163-5.
4. Mbosso EJ, Nguedia JC, Meyer F, Lenta BN, Ngouela S, Lallemand B, Mathieu V, Antwerpen PV, Njunda AL, Adiogo D, Tsamo E, Looze Y, Kiss R, Wintjens R. Ceramide, cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae). Phytochemistry. 2012 Nov;83:95-103. doi: 10.1016/j.phytochem.2012.07.010. Epub 2012 Sep 7.
5. Chichioco-Hernandez C, Wudarski J, Gevaert L, Verschaeve L. Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants. Pharmacogn Mag. 2011 Apr;7(26):171-5. doi: 10.4103/0973-1296.80683.
6. Sackeyfio AC, Lugeleka OM. The anti-inflammatory effect of a crude aqueous extract of the root bark of "Ficus elastica" in the rat. Arch Int Pharmacodyn Ther. 1986 May;281(1):169-76.
7. Carey AB, Cornish K, Schrank P, Ward B, Simon R. Cross-reactivity of alternate plant sources of latex in subjects with systemic IgE-mediated sensitivity to Hevea brasiliensis latex. Ann Allergy Asthma Immunol. 1995 Apr;74(4):317-20.

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