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Peristrophe roxburghiana

Synonyms

Peristrophe bivalvis (Linn.) Merr., Peristrophe baphica (Sprengrl) Bremekamp, Peristrophe tinctoria (Roxb) Nees, Justicia bivalvis Linn, Justicia baphica Sprengel, Justicia roxburghiana Roemer & Schultes, Justicia tinctoria Roxburgh, Hypoestes bodinieri H. Leveille

Vernacular Names:

China Hong-si-xian, Hung-ssu-hsian, Guan-yin-cao, Kuan-yin-ts’ao
 Vietnam  La cam [1] [2] [3]

General Information

Description

Peristrophe roxburghiana is a member of the Acanthaceae family. It is a perennial herbs which can reach up to 40 cm high. The stem is 5- or 6-angles with much branching, sucate and pubescent. The leaves are opposite, ovate meausring 4-9 cm long and 2-4 cm wide. They are subentire, acuminate with base cuneate and both surfaces are puberulent. Petiole 3.5 cm. The flowers are rose-purple with foliaceous bracts that are ovate and 2 subtending a small fascicle. The base is subcordate and apex acute. The calyx measures 4.5-5 mm, pubescent; lobes lanceolate. The corolla is pink  measuring 3.5-5.7 cm outside puebsecnt with non-glandular trichones. The staminal filament is 1.3 cm long puberulent; anther thecae linear, subequally to unequally inserted. The ovary is pubescent; style glabrous; stigma 2-cleft. The capsule is 1.5 cm pubescent. The seeds measure 1.5 x 1.5 mm. [1] [8]

Plant Part Used

Whole plant [1]

Chemical Constituents

Total polyphenol                       17.7 micromol catechin/g

Free polyphenol                         11.5 micromol catechin/g

Percentage free polyphenol      65.7%

peristrophamide; peristrophine [3] [4]

Traditional Used:

Peristrophe roxburghiana is essentially a plant used in traditional Chinese medicine. It is believed to clear heat and resolve toxins, cool the blood and extinguish wind. It also dissipate stasis and disperse swelling. [1]

Respiratory Diseases

The plant has been advocated for use in the treatment of various respiratory conditions especially cough and haemoptysis. It is also used in the treatment of tuberculosis. [2]

Inflammatory Diseases

It is used to treat tonsillitis, sores in the mouth and tongue, swelling due to abscesses, knocks and falls, and scrofula. The anti-inflammatory activity renders it useful in the treatment of snake bites. [2]

Pre-Clinical Data

Pharmacology

Antithrombotic activity

Hemorrheological parameters (hematocrit, fribrinogen level, plasma viscosity and apparent whole blood viscosity) are primary risk factors in ischaemic heart disease. The extract from P. roxburghiana showed ability to decrease effectively many hemorrheological parameters while at the same time was found to inhibit thrombus formation. [5] 

Antihypertensive activity

Extract of P. roxburghiana was found to have the ability to reduce high blood pressure in rats. At the same time it increases the levels of NO and NO-synthase in the serum and NO in urine. It also reduces the concentration of ET in serum and that of angiotensin II in the thoracic artery. Thus, the possible mechanism of the anti-renovascular hypertensive activity it through increasing NO in serum and decreasing angiotensin II in thoracic aorta. [6] [7]

Antioxidant activity

Fresh P. roxburghiana has 64% free polyphenols within its substance rendering it active as an antioxidant. It showed significant free radical scavenging activity (EC50 = 10) and LDL oxidation inhibition activity (IC50 = 34.2 [total] and 44.9 [free] too. [3]

Toxicities

No documentation

Teratogenic effects

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

There is a potential additive effects of this plant with anticoagulant therapy and antihypertensive therapy. Your doctor should be made aware if you are on these drugs and taking this herb together. [5] [6] [7]

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Hu SY. Food Plants of China China University Press, Hong Kong. 2005; pg. 676
  2. Zhou J., Xie G., Yan X., Encyclopedia of Traditional Chinese Medicine: Molecular Structures, Pharmacological Activities, Natural Sources and Application Volume 5, Springer, Berlin. 2011; pg. 520
  3. Thu NN., Sakurai C., Uto H., Chuyen NV., Lien DTK, Yamamoto S., Ohmori R., Kondo K. The Polypheonol Content and Antioxidant activities of the main edible vegetables in Northern Vietnam, Journal of Nutritional Science and Vitaminolgy. 2005
  4. Qin JP, Xu XJ, Wu LZ, Ling ZJ, Pu QL. Structure elucidation of two compounds from Peristrophe roxburghiana Acta Pharmaceutica Sinica .1999-08
  5. Yang W, Gu F, Lü J, Yang M. [Effect of the extract from Peristrophe roxburghiana on hemorheology in rats]. Zhong Yao Cai. 2002 Oct;25(10):727-8.
  6. Zhung X., Lu J., Yang W, Yang M. [Effects of Peristrophe roxburghiana on blood pressure. NO and ET in renal hypertensive rats]. Zhong Yao Cai. 2003 Apr;26(4):266-8
  7. Cheng Z, Lü J, Liu J. [Effects of Peritrophe roxburghiana on blood pressure in renal hypertensive and hyperlipidemic rats]. Zhong Yao Cai. 2004 Dec;27(12):927-30.
  8. Flora of China: Volume 19 – Acanthaceae. pg. 465 - 466. Available from: http://flora.huh.harvard.edu/china/mss/volume19/Flora_of_China_Volume_19_Acanthaceae.pdf. [Accessed on 30th April 2013]

 

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