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Zingiber aromaticum Val.

Synonyms

No documentation

Vernacular Names:

Malaysia Lempoyang Wangi, lempoyang [1], lampoyang, tepus [9]
Indonesia Lampuyang wangi, lampuyang pahiit (Javanese) [9]; lempuyang wangi, lempuyang rum, lampujang room, lempuyang emprit [10],

General Information

Description

Zingiber aromaticum is a member of the Zingiberaceae family. It is a moderate sized herbaceous plant with stem reaching up to 30-45cm tall. The young stems are green turning purple when matured. The rhizome is pale yellow and very aromatic. The leaves are lanceolate, glabrous except on the midrib on the undersurface, measuring 10-15cm long and 6-8cm wide. The spike is oblong and blunt, 8cm long. The flowers have white lobe and the lip is pale yellow with orange central stip. [1]

Plant Part Used

Rhizome and young shoots. [1]

Chemical Constituents

(S)-6-gingerol; (2R,3S,5R)-2,3-epoxy-6,9-humuladien-5-ol-8-one; (2R,3R,5R)-2,3-epoxy-6,9-humuladien-5-ol-8-one; (5R)-2,6,9-humulatrien-5-ol-8-one; 2,9-humuladien-6-ol-8-one; humulatrien-5-ol-8-one; kaempferol-3-O-(2,3-di-O-acetyl-alpha-l-rhamnopyranoside); kaempferol-3-O-(2,3,4-tri-O-acetyl-alpha-l-rhamnopyranoside); kaempferol-3,4'-di-O-methyl ether; zerumbone. [3-5][8]

Traditional Used:

The rhizome is used to heat the body and as antiflatulance. It is also used to increase appetite in children. The young shoot is used in cooking as a taste enhancer. [1] 

It is also used in childbirth. In Indonesia it is believed to be analgesic, stomachic and stimulant. It is being prescribed as a treatment for asthma, cough, diarrhoea, loss of appetite, colic, jaundice, worm infestation and as a contraceptive. [2]

Preclinical Data

Pharmacology

CYP3A4 and CYP2D6 inhibitory activities

A number of compounds isolated from the rhizome of Z. aromaticum exhibited inhibitory activities on the enzymes CYP3A4 and CYP2D6. Some of these compounds include kaempferol-3-O-(2,3,4-tri-O-acetyl-alpha-I-rhamnopyranoside inhibiting CYP3A4, and kaempferol-3-O-methyl ether inhibiting CYP2D6. The mechanism-based inhibition of the kaemferol glycosides are irreversible. [3-6]

Protein tyrosine phosphatase 1B inhibition activity

Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as a the mechanism for the treatment of type 2 diabetes and obesity. The following compounds, humulatrien-5-ol-8-one (21; IC50, 27.7μM), kaempferol-3,4'-di-O-methyl ether (32; IC50, 17.5μM), and (S)-6-gingerol (33; IC50, 28.1μM),  isolated from the rhizome of Z. aromaticum exhibited this activity. [7]

Antitumour activity

The compound zerumbone was isolated from the extract of Z. aromaticum rhizome. This compound is a sesquiterpenoid which exhibit significant anticancer property via its apoptosis-inducing and antiproliferative activity. [8]

Toxicities

No documentation

Teratogenic effects

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Mat-salleh K. Latiff A., Tumbuhan Ubatan Malaysia Universiti Kebangsaan Malaysia Bangi 2002, pg.653 – 654
  2. Sobiyo BRAM. Alam Sumber Kesihatan; Manfaat dan Kegunaan, Balai Pustaka, Jakarta 1997 pg. 247 – 248
  3. Usia T, Iwata H, Hiratsuka A, Watabe T, Kadota S, Tezuka Y. Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. J Nat Prod. 2004 Jul;67(7):1079-83.
  4. Usia T, Watabe T, Kadota S, Tezuka Y. Mechanism-based inhibition of CYP3A4 by constituents of Zingiber aromaticum. Biol Pharm Bull. 2005 Mar;28(3):495-9.
  5. Subehan, Usia T, Kadota S, Tezuka Y. Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):333-5.
  6. Usia T, Iwata H, Hiratsuka A, Watabe T, Kadota S, Tezuka Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006 Jan;13(1-2):67-73. Epub 2005 Jun 29.
  7. Saifudin A, Kadota S, Tezuka Y. Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum. J Nat Med. 2013 Apr;67(2):264-70. doi: 10.1007/s11418-012-0674-7. Epub 2012 May 30.
  8. Kirana C, McIntosh GH, Record IR, Jones GP. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer. 2003;45(2):218-25.
  9. Burkill IH. A dictionary of the economic products of the Malay Peninsula. Volume 2. London: Published on behalf of the governments of the Straits settlements and Federated Malay states by the Crown agents for the colonies; 1935. p. 2293.
  10. Sastroamidjojo AS. Obat asli Indonesia. Jakarta: Penerbit Dian Rakyat; 1988. p. 350-351.

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