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Tabernaemontana corymbosa Roxb.

Synonyms

Ervatamia corymbosa King & Gamble [3]

Vernacular Names

Malaysia Jelutong Badak, Susun Kelapa, Susok Ayam, Pokok Restung, Restong Badak, Seratong, Pokok Setong
English Pinwheel Flower, Flower of Love
China San Fang Gou Ya Hua
Indonesia Jelutong Badak [1-3]

General Information

Description

Tabernaemontana corymbosa is a member of the Apocynaceae family. It is a shrub or small tree. The leaves are elliptic (15-40cm long) and coriaceous. The petiole base is enlarge and clasping the stem. The corymbs are in the upper axils, much branched. The corolla is cream white, follicles ovoid, curved, beaked, 3.5-4cm long. [1]

Plant Part Used

Bark, leaves, roots, latex. [2][3]

Chemical Constituents

3R/S-ethoxyheyneanine; 3R/S-ethoxy-19-epi-heyneanine; 7(R)- geissoschizol oxindole; 7(S)-geissoschizol oxindole; 7(R),16(R)- 19(E)-isositsirikine oxindole; 7(S),16(R)-19(E)-isositsirikine oxindole; 19'(S)-hydroxyconodurine; 19'(S)-hydroxyconoduramine; 19'(S)-hydroxyervahanine A; 19(S)-hydroxyibogamine; 19-epi-isovoacristine; 19’(S) hydroconoduramin; 19’(S)-hydroxyyervahanine A; N(4)-demethyltaberpsychine;  conodiparines A-F; conodurine; conodurinine; conodutarines A and B; cononitarines A and B; ervahanine A; isovoacryptine; jerantinine A – H;jerantiphyllines A and B; tabersonine hydroxyindolenine; vincamine [2][4-10]

Traditional Used:

In China, the bark and leaves are used for the treatment of fractures. The roots are used in Malaysia to recover from childbirth and exhaustion, and a paste of the plant is used to treat orchitis. [2][3]

Latex is used in the treatment of ulceration of the nose in tertiary syphilis (restung). [3]

Pre-Clinical Data

Pharmacology

Cytotoxic activity

Five alkaloids (jerantinines A-E) isolated from T. corymbosa showed pronounced in vitro cytotoxicity against human KB cells (IC50<1µg/ml). Conodiparines showed significant activity in reversing resistance in vincristine-resistant KB cells. [6][10]

Toxicities

No documentation

Teratogenic effects

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Keng H. The Concise Flora of Singapore: Gymnosperms and Dicotyledons Volume 1. Singapore: Singapore University Press; 1990. p. 145.
  2. Wiart C. Ethnopharmacology of Medicinal Plants: Asia and the Pacific. Berlin: Springer-Verlag; 2006. p. 74.
  3. Burkill IH. A Dictionary of Economic Products of the Malay Peninsula Volume 1. Kuala Lumpur: Ministry of Agriculture and Cooperative Malaysia; 1966. p . 957.
  4. Lim KH, Sim KM, Tan GH, Kam TS. Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana. Phytochemistry. 2009 Jun;70(9):1182-6. doi: 10.1016/j.phytochem.2009.06.010. Epub 2009 Jul 28.
  5. Lim KH, Thomas NF, Abdullah Z, Kam TS. Seco-tabersonine alkaloids from Tabernaemontana corymbosa. Phytochemistry. 2009 Feb;70(3):424-9. doi: 0.1016/j.phytochem.2009.01.001. Epub 2009 Feb 11.
  6. Lim KH, Hiraku O, Komiyama K, Kam TS. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2008 Sep;71(9):1591-4. doi: 10.1021/np800435c. Epub 2008 Sep 9.
  7. Kam TS, Sim KM. Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa. Phytochemistry. 2003 Jul;63(5):625-9.
  8. Kam TS, Sim KM, Pang HS. New bisindole alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2003 Jan;66(1):11-6.
  9. Kam TS, Sim KM. Five new iboga alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2002 May;65(5):669-72.
  10. Kam TS, Sim KM, Koyano T, Toyoshima M, Hayashi M, Komiyama K. Conodiparines A-D, new bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1693-6.

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