The Adjuvant Effect Of Subgingivally Delivered Sea Cucumber Extract Gel In Non-Surgical Therapy Of Chronic Periodontitis






sea cucumber, effectiveness and safety, chronic periodontitis


The effectiveness and safety of a subgingivally delivered Sea Cucumber Extract gel and vehicle control were evaluated in a 12-week clinical trial. This randomized, split-mouth, placebo controlled clinical trial was conducted in patients diagnosed with generalized chronic periodontitis who had teeth with 6 to 9 mm periodontal pockets. A total of 30 pairs of teeth were chosen from 16 subjects selected from referrals to the Department of Oral Pathology, Oral Medicine and Periodontology in the Dental Faculty, University of Malaya. The teeth were matched morphologically and were on opposite sides of the oral cavity. The subjects received oral hygiene instructions, full mouth scaling and the selected teeth received root planing at baseline. Subsequently, the test teeth received subgingival application of sea cucumber extract gel and the control teeth subgingival application of placebo gel. This application was done at baseline, one week later and two weeks later. Clinical parameters were measured at baseline prior to treatment, at 4-week, 8-weck and 12-week intervals. These parameters were probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding on probing (BOP), mobility index (MI), gingivitis index (GI) and plaque index (PI). Wilcoxon Matched-Paired Signed-Rank Test was used to compare the mean reductions in measurements between baseline to the 4th, 8th and 12th week for test and control teeth for pockets of all depths and 6 to 9 mm pockets. The statistical analysis showed no significant difference between test and control teeth for all parameters, although the PPD and CAL measurements were consistently better for test teeth in the deep pockets (6 to 9 mm).