Effect of Hydro-Alcholic Extract of Securigera securidaca Seeds on Normoglycemic and Streptozotocine Induced Diabetic Rats


Nikbakht Mohamad Reza, Gheatasi Izadpanah, Sadeghi Heibatollah, Sabzali Vida, Sabzali Sohaila and Shahrani M


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Diabetes, Securegera securidaca, streptozotocine


Diabetes mellitus is a metabolic disorder of carbohydrates, lipids and proteins that caused by deficiency or lack of insulin. Usage of chemical agents and unwished complication of these drugs increased the inclination for use of medical plants with low complication.Securigera securidacais one of the medicinal plants claimed to have antiepileptic, diuretic, hypotensive and hypoglycemic effects. In this study we evaluate the hypoglycemic effect of hydro-alcoholic extract ofS. securidacaseeds on streptozotocine induced diabetic rats. 70 male albino Wister rats have been selected and randomly divided to seven groups. Diabetes was induced by intravenous (tail vein) injection (45mg/kg) of streptozotocine.S. securidacaseed extract was used orally in dosage of 500, 1000 and 2000 mg/kg body weight. The blood glucose was measured before and one, two and three weeks after treatment with the extract. Streptozotocine significantly increased the blood glucose.S. securidacaextract in doses of 500 and 1000 mg/kg after two weeks don’t have significant effect on blood sugar but 2000 mg/kg of extract significantly decreased the blood glucose. The extract has not significant effect on blood sugar in normal glycemic rats. The results of this study are indicating thatS. securidacaseed extract at dose-dependent decreased the blood glucose in streptozotocine induced diabetic rats.