The Role of Menthol in Napkin Dermatitis


Sabzghabaee Ali Mohammad, Nili Firouzeh, Ghannadi Alireza and Anvari Maryam


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia.




Menthol, napkin dermatitis, clinical trial


Regarding to antibacterial, antifungal and probable anti inflammatory effects of the essential oil extracted fromMentha pipperita, its role in the treatment of ND was evaluated in a randomized single blind placebo controlled parallel group clinical trial. The study design was single blind randomized placebo controlled parallel group clinical trial and the project was done in department of neonatology at Valiasr general teaching hospital affiliated with Tehran university of medical sciences (Iran). Eligible neonates with diagnosis of candidial napkin dermatitis, no need of critical care and not on systematic antifungals and anti-inflammatory drugs were included in the study. 106 patients were randomly allocated in two groups: cases, standard therapy-topical clotrimazole - plus menthol drop applied topically and controls, standard therapy plus placebo from which 35 neonate in each group were fully evaluated for skin rash before and on the 1st, 3rd, 5th and 7th day of therapy using Munz and Concannon rash scoring methods. Demographic data and total skin rash score before study was not significantly different in both arms (p>0.05). The total course of therapy for complete healing were found to be shorter in the case group (4.3±1.6 vs. 6.9±1.8 p=0.0001) and erythema and pustules had a significant (p=0.0001) relief in the case group. No known and severe adverse effect of drug was observed during the study. It seems that topical application of menthol may have a clinical role in treatment of candidial napkin dermatitis.