Toxicity Evaluation of Herbal Products: Something Achievable


Zakiah Ismail and Noor Rain Abdullah


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007, Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




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The preference to use traditional & complementary medicine is the scenario worldwide that also seen in Malaysia. While such practice is encourage to be implemented as part of medicinal practice in provision of holistic health care, many issue related to its used especially for products, is remain unsettle and require urgent attention. This had been discussed in numerous occasion either at national and international level, resulting with many guideline and requirement been published in order to harmonies the approach taken. For Safety evaluation, OECD and FDA documents that were developed for pharmaceutical or chemical has been referred. In Malaysia, such move has been started since 1990s where products that have promising potential were subjected to preclinical toxicity evaluation. Although this evaluation that involvein-vivousing two different species of animal models andin-vitrocells studies are fairly challenging, we were able to initiate and manage to establish the facility as part of conducting few national projects. We found that out of five standardized herbal products studied, four were safe while one was demonstrating teratogenic potential. We also studied few industry products and all were shown not causing any adverse reaction. This experience had provide us the first milestone of many step towards meeting the international Good Laboratory Practice requirement.