Analgesic Effect of Aqueous Satureja hortensis  L. Seed Extract in Rat Male


Javad Verdi, Masoumeh Sabetkasaie, Shiva Sharif1 and Mohammad Kamalinejad


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Satureja hortensis lamiaceae, analgesia, formalin test


There are some reports concerning effects of the plantSatureja hortensisL. in Iranian traditional medicine. For evaluation of the possible analgesic effect of this plant, the chronic (formalin test) and acute (tail flick) pain models were used in male rats. Administration of 62.5, 125, and 250 mg/kg (i.p.) of aqueous extract of this plant did not show any effect in the tail flick test. However, these doses of the extract produced significant analgesic effect in the first and second phases of the formalin test (p<0.001). Sodium salcylate (300 mg/kg, i.p.) only induced analgesia in the late phase of the formalin test. It can be concluded that the analgesic effect of the extract is more effective through intraperitoneal route that oral one, the analgesic effect of 250mg/kg of the extract was more potent than 62.5 and 125 mg/kg of the extract (i.p.) and 300 and 500 mg/kg of the extract (p.o.) and 300 mg/kg (i.p.) of Sodium salcylate, and since aqueous seed extract ofS. hortensisL. affects both phases of the formalin test, it produces its analgesic effect through central mechanism. In addition, the analgesic effect of the extract may be attributed to its flavonoid and trepenoid content.