In vitro Antiproliferative Effects of Peganum harmala  Seeds Extract


Parvaneh Rahimi-Moghaddam, Maryam Karjalian and Massoud Mahmoudian


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Leishmaniasis, Peganum harmala, antiproliferative


Leishmaniasis is an infection caused by protozoa of the genus leishmania presenting several forms of disease. Many efforts have been made to find effective extract of several desert plants against cutaneous leishmaniasis lesions, caused by L. major. This work describes the in vitro antileishmanial activity ofPeganum harmala. Antimicrobial, antifungal and antiprotozoal effects ofP. harmalahave been reported. Promastigotes of L. major were grown at 26°C and incubated with several concentrations of theP. harmalaseed extract solubilized in dimethyl sulphoxide (DMSO) and then counted in aneubauer’s chamber. Controls without the drugs and with DMSO were done in parallel. The results showed that theP. harmalaseeds extract had a good antileishmanial activity. Because of its appreciable efficacy in destroying parasites,P. harmalaseeds extract may be considered for treatment of cutaneous leishmaniasis.