Drug Discovery and Traditional  Medicine: With Respect to High Throughput Screening


Mahmoud Mosaddegh and Farzaneh Naghibi


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia.




Data not available


Drug discovery or drug development is a long and cost effectiveness process. However, new drugs for most diseases such as cancer, aids, etc. are still on demand. Discovering or developing a new drug is based on either chemical or natural component. Recently biological entities also have been used. Among them, natural components have very significant places in introducing new drugs or at least new lead compound. In this regard, ethnomedicine, ethno pharmacy, ethno pharmacology, ethno botany, folk medicine and above all traditional medicine can play a great role to discover new drug. These knowledge can help to select plants in a better way and more cost effectiveness way. It is assumed that out 250000 higher plant species only about 6% have been screened for biological effects. Despite their elimination from drug discovery pipeline, natural products, in particular, remain attractive targets for discovery of novel bioactive molecules. However, a significant obstacle to this is the cost and delay associated with compound separation and purification that is applied to all plant prior to evaluation of biological activity. Efforts to accelerate and rationalize drug discovery have led to high throughput screening (HTS). HTS process is now perhaps the principle strategy for the discovery of new lead compound in the pharmaceutical industry. In this paper we try to explain drug discovery based on traditional medicine by means of HTS.