Effects of Valeriana officinalis on Pentylentetrazol-induced Convulsion


B.F. Baha-aldini B. and Kh Zarifi


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007),Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Valeriana officinalis , convulsion, anxiolytic, animal model


Roots ofValeriana officinalis (v. officinalis) has been investigated for its sedative, anxiolytic and analgesic effects widely. But there is limited data about its anticonvulsant effects. The aim of this study was to find out the effective fraction and doses ofV. officinalisin the animal model of absence seizure. Pentylenetetrazol (PTZ) 90mg/kg, was injected (SC) to induce convulsionin mice. Four different extracts (aqueous, hydro alcoholic, ethanolic, and essence) and different doses ofV. officinaliswere prepared and adequate volume were injected to different animal groups  (n=5) before PTZ administration. Incidence and latency time of convulsion and death time were recorded. Two extracts (hydro alcoholic and essence) increased the latency of convulsion and death time and decreased the incidence of the attack significantly (P<0.05). Our data show that there is a good possibility forV. officinalisto have a potential anticonvulsant effect against absence seizure in human.