Evaluation of the Hepatoprotective Effect of Dried Fruits of Vitis vinifera


Farshad Roshanzamir, Mohammad Kamalinezhad and Soheila Rezai


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




hepatoprotective, Vitis vinifera, grape


One of the plants with different variety in Iran isVitis vinifera. The importance of this plant lies on the fact that the dried juice of its fruits is used extensively as hepatoprotective agent in folk medicine. This prompted us to study the hepatoprotective effects of blackcurrants. Concentrated extract of dried grape was prepared by adding hot water to dried grapes and then concentrating on steam bath. The extract was then used at the amounts of 5, 2.5, 1.25, 0.5, 0.25, 0.1, 0.075, 0.05 and 0.01 g/kg BW on male rats which their liver function had been damaged using CCl4. SGOT and SGPT enzymes were measured before and after administration of the extract and the results showed that the high level of SGOT and SGPT (due to the CCl4-induced liver damage) are significantly decreased after using the grape extracts. The observed hepatoprotective effect of the extract ofV. viniferacould be attributed to the free radical scavenging effect of the extract.