The Effect of Seed Extract of Grape Fruit on Candida albicans Compare With Other Common Antifungal Drugs


Malekan M , Fallah F, Karimi A, Navidinia M and Hooshmand A


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007),Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Candida albicans, vaginitis, seed extract


Vaginitis is an infectious or non infectious and inflammatory disease and may caused by bacterial, fungal and other agents. Since there is a high prevalence of vaginitis in majority of communities including Iran, treatment of this disease is so crucial. The effect of grape fruit seed extract consist varieties of flavonoids, was investigated on microbial agents causing the vaginitis in this study. Vaginal discharges from 100 patients suffered from vaginitis that referred to medical centers of Tehran, were taken and transported them to laboratory. These samples were stained with Gram stain and cultured on specific and general media. The agents were identified and their susceptibilities to antibiotics were determined. The grape fruit seeds were provided from Tonekabon city of mazendaran province. Aqueous and ethanolic extracts were made from seeds and affect them on infectious agents as different concentrations by MIC method for determining their susceptibilities to given antibiotics. 25-30 aged women and girls suffered vaginitis. 40% of them were infected withCandidae. The isolated candida from studied patients, were resistant to clotrimazole and fluconazol. No significant effect was seen from aqueous extract but important results were seen from ethanolic extract on infectious agents, primarily those resistant candidas. It could be predicted from this study that grapefruit seed extract may be promising drug-like for treatment of vaginitis.