Effects of Piper sarmentosum Extract and Glycyrrhizic Acid on Plasma Lipid Profile in Ovariectomized Rats


Aida Azlina Ali, Farihah Haji Suhaimi, Qodriyah Haji Mohd Saad and Nur Azlina Mohd. Fahami


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Piper sarmentosum, glycyrrhizic acid, lipid


This study was conducted to evaluate the effects ofPiper sarmentosum(PS) extract and glycyrrhizic acid (GCA) on plasmalipid profile in ovariectomized rats. Twenty-eight female Sprague-Dawley rats were randomly divided into four groups. Three groups were ovariectomized (OVX), while the remaining group underwent sham operation. The OVX groups were given PS extract (0.125g/kg), GCA (0.120g/kg) and water (CTRL) respectively, while the sham-operated (SHM) group received only water daily for 5 months. Plasma lipid profile was measured before the surgery, at 0 (basal), 3 and 5 months of treatment. Our results showed that all the three groups OVX rats had a significant increase (p<0.05) in the plasma total cholesterol(TC), triglyceride (TG) and low-density lipoprotein (LDL), and significant reduction (p<0.05) in high-density lipoprotein (HDL)level compared to the SHM group. After 3 and 5 months of treatment, both PS and GCA treated group showed a significant reduction (p<0.05) in the plasma TC, TG and LDL and a significant increase (p<0.05) in HDL. However, in the GCA treated group the plasma HDL increment and LDL reduction was smaller (p<0.05) compared to the PS treated group after 3 and 5 months of treatment respectively. In conclusion, PS is suggested as a possible alternative therapy for hyperlipidemia based on the positive effects on lipid profile.