Inhibition Of Platelet Aggregation By Acidic and Neutral Components Of Pinus massoniana Resin


H, T. A. Cheung. S. L. Fu, M. P. Lenguyen, T. Miyase# and M. A. Smal. Department of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.


Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




Pinus massoniana resin, platelet aggregation inhibition, levopimaric acid, longifolene, ß-caryophyllene oxide.


The resin of Pinus massoniana Lamb, contains 17 diterpene and trisnorditerpene acids of which 15-hydroxy-7, 13-abietadien-12-on-18-oicacid (14) and8(14)-podocarpene-7,13-dion-18-oicacid (17) are new compounds. Levopimaric acid (2), pimaric acid (1) and two other diterpene acids, as well as longifolene and ß -caryophyllene oxide from the neutral fractions, inhibit in vitro the aggregation of rabbit platelets induced by some or all of the following agonists: platelet activating factor, adenosine 5'-diphosphate and calcium ionophore A23187.