Effect Of Medium Long Term Feeding Of Edible Oils On Blood Pressure Of Rats And the Response To Injected Noradrenaline


Ima Nirwana Soelaiman1, Zainuddin Merican1, Khalid Abdul Kadir2, Jamaluddin Mohamed3 and Baharom Suboh.1 Depts. of Pharmacology1, Medicine2 and Pathology3 Universiti Kehangsaan Malaysia, Kuala Lumpur, Malaysia.


Trends in Traditional Medicine Research ,Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




Palm oil, arterial blood pressure


Systolic and diastolic blood pressure (SBP and DBP) comparison were made between male normotensive rats fed with different oils for 4 and 9 months. Older rats had higher increases in DBP upon being given intravenous noradrenaline (NA) in increasing doses compared to younger rats (p < 0.05). No significant difference in basal SBP and DBP between dietary groups at 4 months and 9 months treatment were seen. At 4 months treatment, DBP of the coconut oil and ghee groups were higher than the palm oil (p < 0.05) and control (p < 0.05) groups at several NA doses. SBP of the coconut oil and ghee groups were higher than the palm oil (p < 0.05) group at several NA doses. These differences were not seen at 9 months treatment. The results suggest that palm oil has a temporary beneficial effect on arterial blood pressure in rats as compared to coconut oil and ghee.