Effect Of Crude Water Extract Of Sea Cucumber (Stichopus sp.) On Conditioned Avoidence Response In The Rat


Peng-Nam Yeoh. Hassan Yaacob, Mohd. Shahimi Mustapha1 and Ismail Getah, Department of Pharmacology, Faculty of Medicine, University of Malaya. 59100 Kuala Lumpur 1Department of Pharmacology, Faculty of Medicine, University Kehangsaan Malaysia, Kuala Lumpur


Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




Stichopus sp. gamat, sea cucumber, conditioned-avoidance-response.


The crude water extract of the Malaysian sea cucumber or gamat (Stichopus spl) significantly prolongs (P<0.01) the reaction time of rats to conditioned-avoidance-response, (CAR), using sound and light as the conditioned stimulus (CS) and electric shock, as the unconditioned stimulus (UCS). However the escape response remained intact. The CAR was also prolonged by aspirin, which was less potent than the crude water extract.