Screening Of Active Anti-Inflammatory Molecules In Leaves Of Emblica offinalis


Jari Summanen*, Hannu Kankaanranta#, Eeva Moilanen#, Zaini M. Asmawi, Raimo Hiltunen, Heikki Vuorela and Heikki Vapaatalo *Pharmacognosy Division, Department of Pharmacy, P.O. Box 15 and Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014 University of Helsinki, Finland; #Department of Biomedical Sciences, University of Tampere, P.O. Box 607. FIN-33101 Tampere, Finland; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia


Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




Emblica officinalis; Euphorbiaceae; leaves; anti-inflammatory compounds; polymorphonuclear leukocytes; migration; leukotrienes; thromboxanes.


Leaves of Emblica officinalis were extracted with ten different solvents (n-hexane, diethylether, methanol, tetrahydrofuran, acetic acid, dichloromethane, 1,4-dioxane. toluene. Chloroform, water). Methanol. tetrahydrofuran and 1,4-dioxane extracts were potent inhibitors of human polymorphornuclear leukocyte migration (50 µg/ml causing ca 90 % inhibition). Diethylether extract inhibited leukotriene B4 production in polymorphornuclear leukocytes as well as thromboxane B2, synthesis in platelets during clotting (50 µg/ml;  causing ca 50 and 40 % inhibition, respectively).