Effect Of Labisia pumila var alata (Kacip Fatimah) On Body Weight In Ovariectomy-Induced Obese Sprague dawley Rats


Ayida Al-Wahaibi1, Wan Nazaimoon2, Farihah HS2, Azian AL, 1Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, 2Diabetes and Endocrine Unit, Institute Medical Research, Malaysia


1st International Conference & Exhibition on Women's Health & Asian Traditional (WHAT) Medicine




menopause, herbal, Labisia pumila var alata, 'Kacip Fatimah', body weight,


Menopause is a normal and natural event that marks the end of menstruation and it affects women differently. Some women notice little difference in their bodies or moods, while others find the change extremely disruptive. Postmenopausal women are at high risk of weight gain, especially those already characterized by increased weight and fat mass, coronary diseases and stroke as well as osteoporosis and fractures. Kacip Fatimah is a traditional herb used by Malay women to induce and facilitate childbirth as well as a postpartum medicine.   It is usually prepared by boiling over low heat and the water decoction taken as a drink.  In this study, a group of 6 months old female ovariectomized (OVX) Sprague Dawley rats were randomly divided into 3 groups to receive daily treatment of either; Estrogen replacement therapy (ERT) (64.5µg/kg/day) or Kacip Fatimah (KF) (17.5 mg/kg/day) for a period of three months.  The third group was used as control (OVXC) and received only water.  Nine rats were left intact and used as normal control (NOR). Results showed that ovariectomy induced a significant increase (P < 0.05) in body weight compared to the NOR group; 5.5%, 43%, 23.4%, and 21.9% for NOR, OVXC, ERT and KF respectively. In the second month, increases in body weight of ERT- and KF-treated rats were only 0.9% and 0.4% respectively.  In contrast, there was 2.2% and 2.9% gain in weight in the NOR and OVXC groups respectively. By the third month, mean weight of ERT-treated rats remained unchanged whereas NOR, OVXC and KF showed an increase ranging from 4.6-5.9%. At month-4, all except OVXC group showed decrease in body weight. In conclusion, these results suggest that KF exerts an effect on body weight of OVX rats and warrants further investigation.