The Safety Profiles Of Labisia pumila var. alata In Post Menopausal Women


1Azidah AK, 1Nik Hazlina NH, 1Wan Mohamad WB, 1Intan IH ,2Wan Nazaimoon WM, 3Norlela S,3Nor Azmi K, 1School of Medical Sciences, Universiti Sains Malaysia, 2Institute for Medical Research, Kuala Lumpur, Malaysia, 3Faculty of Medicine, Universiti Kebangsaan Malaysia


1st International Conference & Exhibition on Women's Health & Asian Traditional (WHAT) Medicine




safety profiles , Labisia pumila var. alata , post menopausal women, randomized, double-blind, placebo-controlled study


Objectives: To evaluate the safety profiles based on biochemical, haematological, radiological and undesirable side effects of varying doses of spray-dried water-soluble extract of Labisia pumila var. alata, a local herb commonly known as Kacip Fatimah.  Methods: This is a randomized, double-blind, placebo-controlled study comparing three different doses of spray-dried water-soluble extract of Kacip Fatimah among post-menopausal Malay women aged 48-55 years old.  Results: A total of 70 patients (50%) completed the study. The mean age and duration of menopause for the participants was 53 years and 2 years respectively. There was significant medical history in 23% of the participants. Hypertension (50%) was the commonest medical problem. There was no significant difference between treatment and placebo groups in renal function test, liver function test, full blood count and coagulation profile. All results of Electrocardiogram, Chest X-tray, mammogram and pelvic ultrasound of the participants were normal. Twelve participants had per vaginal bleed during the study period, however it was not significant between groups. Conclusion: In summary, water-soluble extract of Labisia pumila was observed to be safe in terms of clinical and laboratory evidence among post-menopausal Malay women.