image
Conservation

Compilation of herbal plants (description, geographical distribution, taxonomy, line drawings), biodiversity and herbarium.

Read More
image
Research & Publication

Description of herbal and T&CM research, searchable publication and process from medicinal plant discovery to clinical trial in producing a high-quality registered herbal drug.

Read More
 
Traditional & Complementary Medicine (T&CM)

 

Definition and description of therapies, policy, training and education, research in the practise of (T&CM) and integrated medicine system.           

Read More

 

News Update

Announcement & Advertisement

Forthcoming Events

4th International Conference on Natural Products and Medicinal Plants Research

From Fri, 25. September 2020 Until Sat, 26. September 2020

15th International Conference on Frontiers in Alternative & Traditional Medicine

From Fri, 25. September 2020 Until Sat, 26. September 2020

International Congress on Drug Delivery

From Mon, 5. October 2020 Until Tue, 6. October 2020

Global Pharmaceutical and Pharma Industry Conference

From Mon, 12. October 2020 Until Tue, 13. October 2020

14th International Conference on Pharmaceutics and Drug Safety

From Wed, 21. October 2020 Until Thu, 22. October 2020

Mechanism of antiinflammatory actions of curcumine and boswellic acids.

Author

Ammon HP, Safayhi H, Mack T, Sabieraj J

Date

3/1993

Journal

J Ethnopharmacol

Abstract

Curcumine from Curcuma longa and the gum resin of Boswellia serrata, which were demonstrated to act as anti-inflammatories in in vivo animal models, were studied in a set of in vitro experiments in order to elucidate the mechanism of their beneficial effects. Curcumine inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human platelets. In a cell free peroxidation system curcumine exerted strong antioxidative activity. Thus, its effects on the dioxygenases are probably due to its reducing capacity. Boswellic acids were isolated from the gum resin of Boswellia serrata and identified as the active principles. Boswellic acids inhibited the leukotriene synthesis via 5-lipoxygenase, but did not affect the 12-lipoxygenase and the cyclooxygenase activities. Additionally, boswellic acids did not impair the peroxidation of arachidonic acid by iron and ascorbate. The data suggest that boswellic acids are specific, non- redox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its translocation.

Explore Further

Consumer Data

Consumer data including medicinal herbs, dietary supplement monographs, health condition monographs and interactions and depletions.                                    

Read More
Professional Data

Professional data organized into medicinal herbs, dietary supplement monographs, health condition monographs, T&CM herbs, formulas, health conditions, interactions and depletions.

Read More
International Data

We offer International linkages to provide extensive content pertaining to many facets of T&CM as well as Integrated Medicine. Please register for access.    

Read More