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Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives

Author

Tarasov IuA, Sheibak VM, Moiseenok AG

Date

7/1985

Journal

Vopr Pitan

Abstract

Study of the corticosteroid content in the adrenals and blood of rats under pantothenate deficiency has demonstrated a decrease in adrenocortical function. A single administration of pantothenate in a dose of 3.3 mg/kg reduced the influence of hypovitaminosis on the adrenals. The pantothenate derivatives (pantethine, 4'- phosphopantothenate and CoA in particular) injected to intact animals in a single dose equimolar to 3.3 mg/kg calcium pantothenate per kg bw had a marked steroidogenous effect.

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