Compilation of herbal plants (description, geographical distribution, taxonomy, line drawings), biodiversity and herbarium.

Read More
Research & Publication

Description of herbal and T&CM research, searchable publication and process from medicinal plant discovery to clinical trial in producing a high-quality registered herbal drug.

Read More
Traditional & Complementary Medicine (T&CM)


Definition and description of therapies, policy, training and education, research in the practise of (T&CM) and integrated medicine system.           

Read More


News Update

Announcement & Advertisement

Forthcoming Events

Seminar Tumbuhan Ubatan, Beraroma dan Pegetahuan Tradisi 2020

From Tue, 10. November 2020 Until Wed, 11. November 2020

2nd International Conference on Natural Products & Traditional Medicine

From Mon, 16. November 2020 Until Tue, 17. November 2020

World Congress on Biologics and Biosimilars

From Mon, 16. November 2020 Until Tue, 17. November 2020

14th International Conference on Natural Products Chemistry (ICNPC) 2020

From Thu, 19. November 2020 Until Fri, 20. November 2020

International Conference on Malay Medical Manuscript

From Tue, 15. December 2020 Until Wed, 16. December 2020

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.


Kaehler ST, Sinner C, Chatterjee SS




Neurosci Lett


Hyperforin is the main antidepressant component of hypericum perforatum (St. John's Wort). Using the push-pull superfusion technique we tested whether hyperforin influences extracellular concentrations of neurotransmitters in the rat locus coeruleus. Hyperforin (10 mg/kg, i.p.) not only enhanced the extracellular levels of the monoamines dopamine, noradrenaline and serotonin, but also that of the excitatory amino acid glutamate. The levels of the main serotonin metabolite 5-hydroxyindolacetic acid, as well as those of the amino acids GABA, taurine, aspartate, serine and arginine, were not influenced. Together with in vitro studies, our findings suggest that the antidepressant property of hyperforin is due to enhanced concentrations of monoamines and glutamate in the synaptic cleft, probably as a consequence of uptake inhibition.

Explore Further

Consumer Data

Consumer data including medicinal herbs, dietary supplement monographs, health condition monographs and interactions and depletions.                                    

Read More
Professional Data

Professional data organized into medicinal herbs, dietary supplement monographs, health condition monographs, T&CM herbs, formulas, health conditions, interactions and depletions.

Read More
International Data

We offer International linkages to provide extensive content pertaining to many facets of T&CM as well as Integrated Medicine. Please register for access.    

Read More