Articles

Enhancement of the immune response in mice by Astragalus membranaceus extracts.

Author

Zhao KS, Mancini C, Doria G

Date

11/1990

Journal

Immunopharmacology

Abstract

Astragalus membranaceus extracts injected into normal mice or mice immunodepressed by cyclophosphamide or radiation treatment or by aging are able to enhance the antibody response to a T-dependent antigen. Optimal conditions for maximum effect have been established in normal C3H/HeJ and (C57B1/10 x DBA/2)F1 mice. Enhancement of the antibody response was associated with increase of Th cell activity in normal and immunodepressed mice. The biological activity of endotoxin- free extracts is dependent on the carbohydrate content.