Modified iridoid glycosides as anti-implantation agents. Inhibition of cell adhesion as an approach for developing pregnancy interceptive agent


Misra AP, Mathad VT, Raj K, Bhaduri AP, Tiwari R, Srivastava A, et al




Bioorg Med Chem


Structural modifications in iridoid glycosides and evaluation of their efficacy on adhering capability (in vitro) of immature hamster uterine epithelial cells to the substratum have been studied. Out of 31, eight compounds in vitro, five compounds in utero and two in vivo showed adhesion/implantation preventing activity, respectively. The results provide an indication for further exploration in the line of development of anti-adhesive agents.