Pretreatment of organophosphate poisoning: potential interests of huperzine A

Author

Lallement G

Date

1/2000

Journal

Ann Pharm Fr

Abstract

Pyridostigmine which is widely used as pretreatment of organophosphate poisoning protects cholinesterases of peripheral nervous system. Other molecules able to also protect the central nervous system are under study and, among them, huperzine A. This paper gives an overview of the current investigations about the efficacy and the innocuity of this molecule (study of the mechanisms of action, biological targets, behavioural manifestations) and brings out its potential interests.