Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes.

Author

Lale A, Herbert JM, Augereau JM

Date

3/1996

Journal

J Nat Prod

Abstract

Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin- 1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.