Articles

Melatonin and jet lag: confirmatory result using a simplified protocol

Author

Claustrat B, Brun J, David M, Sassolas G

Date

15/10/1992

Journal

Biol Psychiatry

Abstract

This study replicates the alleviation of jet-lag with melatonin in a simplified protocol for eastward flight. At 22-n hr (n is the time- lag between the North American departure point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n = 15) on the day of the return flight and for 3 consecutive days. On day 8, self- ratings significantly discriminated between melatonin and placebo for global treatment efficacy, morning fatigue, and evening sleepiness.