Articles

Selenium in the maintenance and therapy of HIV-infected patients

Author

Schrauzer GN, Sacher J

Date

6/1994

Journal

Chem Biol Interact

Abstract

Due to its antiviral effects and its importance for all immunological functions, the administration of selenium is suggested as a supportive measure in early as well as in advanced stages of HIV- induced disease. Initial observations on the effects of selenium supplementation in HIV-infected patients indicate that selenium causes symptomatic improvements and possibly slows the course of the disease. As selenium inhibits reverse transcriptase activity in RNA- virus-infected animals, supplemental selenium could also prevent the replication of HIV and retard the development of AIDS in newly HIV- infected subjects. An adequate supply of selenium and of antioxidant vitamins is also proposed as a measure to reduce the probability of the placental transmission of HIV in pregnancy.