Hypoglycemic activity of polypeptide-p from a plant source.

Author

Khanna P, Jain SC, Panagariya A, Dixit VP

Date

11/1981

Journal

J Nat Prod

Abstract

A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.