Articles

Hormone replacement therapy and breast cancer risk.

Author

Koukoulis GN

Date

2000

Journal

Ann N Y Acad Sci

Abstract

The female breast is subject to a lifetime of hormonal control. After menopause, breast tissue becomes quiescent when estrogens drop to low levels. Menopause-associated hormonal decreases produce short- and long-term consequences that can be treated successfully by hormone replacement therapy (HRT). Despite the beneficial effects of HRT, the potential risk of breast cancer is a concern of both women and physicians. The available data indicate that HRT administered for longer than 5 years moderately increases the risk of breast cancer, but overall the benefits outweight the potential risk.