Articles

Monograph:Alpha-Lipoic Acid

Author

Date

8/1998

Journal

Altern Med Rev

Abstract

Alpha-Lipoic acid is a potent antioxidant in both fat- and water-soluble mediums. Furthermore, its antioxidant activity extends to both the oxidized form and its reduced form. DHLA is capable of regenerating ascorbic acid from dehydroascorbic acid, directly regenerating vitamin C and indirectly regenerating vitamin E. Researchers have found lipoic acid to increase intracellular glutathione levels as well as Coenzyme Q10. Clinically, it appears lipoic acid has the potential to prevent diabetes, influence glucose control, and prevent chronic hyperglycemia associated complications such as neuropathy and cataracts. Lipoic acid may also be useful in the treatment of glaucoma, ischemia-reperfusion injury, amanita mushroom poisoning, and cellular oxidative damage.