Thiazide diuretics and calcium metabolism: role in renal lithiasis and osteoporosis


Suarez Fernandez C, Ruilope Urioste LM




An Med Interna


Thiazidic diuretics are first line drugs for treatment of hypertension, due to their proven capacity to reduce cardiovascular morbidity and mortality in hypertensive subjects, including the elderly. In addition, they are very useful in the treatment of heart failure and volumen overload in liver and renal diseases. On the other hand, diuretics are efficacious to prevent calcium-related renal stone formation with or without accompanying hypercalciuria. Finally, related to their capacity to reduce urinary calcium excretion they prevent postmenopausal and senile bone mass loose, and reduce the incidence of hip fracture with relevant socioeconomic consequences.