Triterpene glycosides from Cimicifuga racemosa.

Author

Shao Y, Harris A, Wang M, Zhang H, Cordell GA, Bowman M, Lemmo E.

Date

7/2000

Journal

J Nat Prod

Abstract

Eight new triterpene glycosides named cimiracemosides A-H, respectively, and eight known triterpene glycosides were isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). The new compounds were determined by spectral data to be 21- hydroxycimigenol-3-O-alpha-L-arabinopyranoside (1), 21- hydroxycimigenol-3-O-beta-D-xylopyranoside (2), cimigenol-3-O-alpha-L- arabinopyranoside (3), 12beta-acetoxycimigenol-3-O-alpha-L- arabinopyranoside (4), 24-acetylisodahurinol-3-O-beta-D- xylopyranoside (5), 20(S),22(R), 23(S),24(R)-16beta:23;22:25-diepoxy- 12beta-acetoxy-3be ta,23, 24-trihydroxy-9,19-cycloanost-7-ene-3-O- beta-D-xylopyranoside (6), 20(S),22(R),23(S),24(R)-16beta:23;22:25- diepoxy-12beta -acetoxy-3beta, 23,24-trihydroxy-9,19-cycloanost-7-en- 3-O-alpha-L-arabinopyrano side (7), and 20(S),22(R),23(S), 24(R)-16beta:23;22:25-diepoxy-12beta-acetoxy-3beta,23, 24-trihydroxy-9,19- cycloanostane-3-O-beta-D-xylopyranoside (8).