Single-dose and supplementation studies with cranberry juice relevant to its role in heart disease as an antioxidant.


Vinson, JA, Kharrat HA, Samman N.




American Chemical Society, New Orleans


We performed a long - term study with hypercholesterolemic human subjects, not taking drugs. Nineteen subjects (11 females and 8 males) completed the study that consisted of a fasting baseline sampling and then monthly samplings. Ten of the subjects had CJ with no sugar added and an artificial sweetener. The other subjects consumed regular CJ with sugar. The first month one serving of CJ was consumed, then 2 servings, and finally 3 servings/day. There was no effect of CJ on cholesterol but CJ significantly decreased LDL with 2 servings/day. CJ significantly increased HDL and plasma antioxidant capacity with 2 or 3 servings/day. Triglycerides were elevated at 3 servings/day with the CJ with sugar, but not CJ and artificial sweetener. Thus elevated triglycerides were due to the added sugars in CJ. Two servings/day of CJ significantly improved LDL and HDL, two important parameters that may decrease the risk of heart disease.