Anti-viral cyclam macrocycles : rapid zinc uptake at physiological pH.

Author

Paisey SJ, Sadler PJ

Date

2/2004

Journal

Chem Commun (Camb).

Abstract

NMR and UV-vis spectroscopic studies show that Zn(II) binds to cyclam rapidly at micromolar concentrations, an observation relevant to the anti-viral activity and co-receptor binding of anti-HIV cyclams.